Metformin use related to decrease chance of joint substitute in other folks with sort 2 diabetes

Osteoarthritis is a commonplace power situation that generally reasons joint ache and will also be critical sufficient to require knee and hip replacements. In the USA, the choice of general knee substitute (TKR) and general hip substitute (THR) surgical procedures is estimated to succeed in 572 000 in line with 12 months via 2030. No drugs are recently identified to stop or opposite osteoarthritis.

A workforce of researchers from China, Taiwan and Australia aimed to resolve whether or not metformin use was once related to a decrease chance of TKR or THR as proof so far has been sparse and inconclusive. They analyzed information from 69 706 members who won a prognosis of sort 2 diabetes in Taiwan between 2000 and 2012 and when put next the danger of TKR and/or THR between other folks taking metformin and the ones now not taking metformin. The imply age was once 63 years and part had been girls. About 90% of general joint replacements had been associated with osteoarthritis.

We discovered that metformin use in sufferers with sort 2 diabetes mellitus was once related to a considerably decreased chance of joint substitute, suggesting a possible healing impact of metformin in sufferers with osteoarthritis,” writes Dr. Changhai Ding, Scientific Analysis Middle of Zhujiang Medical institution, Southern Clinical College, Guangzhou, China, with coauthors.

The authors name for randomized managed trials to resolve if metformin use is efficacious in sufferers with osteoarthritis.

Magazine reference:

Zhu, Z., et al. (2022) Metformin use and related chance of general joint substitute in sufferers with sort 2 diabetes: a population-based matched cohort find out about. CMAJ.

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