Can once-weekly administered semaglutide cut back adipose tissue and fats in sufferers with sort 2 diabetes?

Posted through on Mar 5, 2023 in Diabetes mellitus |

In a nutshell

This learn about assessed the impact of subcutaneous semaglutide (Ozempic) on frame composition in sufferers with sort 2 diabetes (T2D). The information confirmed important weight reduction in those sufferers after 3 months of semaglutide remedy according to lowered visceral adipose tissue (VAT) thickness and fats mass (FM).

Some background

T2D is usually related to a gaggle of well being prerequisites that come with hypertension, higher blood sugar, extra frame fats across the waist, and odd ranges of blood ldl cholesterol and triglycerides (a kind of fats). Over the top quantities of VAT (fats tissue round organs) will increase the danger of insulin resistance, T2D, and middle illness. Due to this fact, a significant objective in T2D control comes to the lack of VAT whilst keeping lean frame mass (BM), skeletal muscle tissue (SMM), and energy.

Semaglutide is a drugs that acts just like the hormone glucagon-like peptide 1 (GLP-1). GLP-1 is located to be abnormally low in sufferers with T2D. By way of mimicking the consequences of GLP-1, subcutaneous semaglutide is helping keep watch over urge for food and blood glucose. It additionally ends up in frame weight (BW) loss and lowered possibility of middle prerequisites. Alternatively, its impact on frame composition in a real-life atmosphere in sufferers with T2D stays unclear.

Strategies & findings

This learn about integrated 40 sufferers with T2D. All sufferers had been receiving metformin treatment. Sufferers got once-weekly subcutaneous semaglutide over 26 weeks. Practice-up visits befell at the start of the learn about, after 3 months, and after 6 months. A dose of 0.25 mg of weekly semaglutide used to be given all through the primary consult with. If well-tolerated, this dose used to be maintained for three consecutive weeks, then higher to 0.5 mg weekly. After 3 months, a weekly dose of one mg used to be administered. Frame composition, VAT, muscle energy, and laboratory exams had been carried out.

Decreases in VAT, fats mass index (FMI), and BW had been noticed at follow-up. After 3 months of remedy, VAT, skeletal muscle index (SMI), fat-free mass index (FFMI), waist circumference, and HbA1c (a size of blood glucose keep watch over during the last 2-3 months) ranges had been lowered, then become strong at 6 months. Important weight reduction used to be basically because of FMI and VAT aid.

The base line

This learn about discovered that subcutaneous semaglutide given weekly led to good enough glucose keep watch over, advanced insulin resistance, and advanced frame composition after 6 months of remedy, in a real-world atmosphere.

The superb print

The learn about didn’t come with a keep watch over crew for direct comparisons. This makes it tricky to resolve genuine advantages. Knowledge on vitamin used to be missing. The muscle energy of legs used to be no longer assessed.

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Date :

Jun 14, 2022

Authentic Name :

As soon as-Weekly Semaglutide Induces an Early Growth in Frame Composition in Sufferers with Sort 2 Diabetes: A 26-Week Potential Actual-Existence Find out about.

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